| Autor: |
Masaya, Watanabe, Hisashi, Yokoshiki, Takashi, Noda, Isao, Yokota, Takashi, Nitta, Yoshifusa, Aizawa, Tohru, Ohe, Takashi, Kurita |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International heart journal. 62(6) |
| ISSN: |
1349-3299 |
| Popis: |
Electrical storm (ES), defined by 3 or more occurrences of ventricular arrhythmias within 24 hours, has been shown to be associated with an increased risk of mortality; however, detailed information remains lacking. We aimed to examine the incidence and determinants of ES and its impact on mortality in patients enrolled in the nationwide implantable cardioverter-defibrillator (ICD) registry.We studied 1,256 patients (age 65 ± 12 years) who had structural heart disease with an ICD. The patients were classified into reduced ejection fraction (EF35%; 657 (52%) patients) and preserved or moderately reduced EF (EF ≥ 35%; 599 (48%) patients).ES occurred in 49 (7%) and 36 (6%) patients in the EF35% and EF ≥ 35% groups (log-rank P = 0.297) during the median follow-up of 2.3 years. ICD with resynchronization therapy was associated with a lower incidence of ES in patients with EF35%. Non-ischemic heart disease and diuretics were associated with ES in patients with EF ≥ 35%. During the follow-up, 10/49 (20%) patients with ES and 80/608 patients (13%) without ES died in patients with EF35%, while 7/36 (19%) patients with ES and 38/563 patients (7%) without ES died in those with EF ≥ 35%. We have created 4 Cox multivariate models. All models showed approximately 2-fold higher hazard ratios in patients with EF ≥ 35% compared to EF35%.Our study showed that the determinants of ES differed between EF35% and EF ≥ 35%. The impact of ES for mortality was numerically higher in EF ≥ 35% than in EF35%, although a significant interaction was not detected. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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