Candidate gene study of macular response to supplemental lutein and zeaxanthin
| Autor: | Ekaterina, Yonova-Doing, Pirro G, Hysi, Cristina, Venturini, Katie M, Williams, Abhishek, Nag, Stephen, Beatty, S H Melissa, Liew, Clare E, Gilbert, Christopher J, Hammond |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Fatty Acid Desaturases cis-trans-Isomerases macular degeneration Genotype LZ lutein and zeaxanthin L lutein Xanthophylls Polymorphism Single Nucleotide Article macular pigment Young Adult Delta-5 Fatty Acid Desaturase Quantitative Trait Heritable Zeaxanthins Twins Dizygotic Humans genetics Prospective Studies MPOD macular pigment optical density Chromatography High Pressure Liquid lutein Genetic Variation Twins Monozygotic CAREDS Carotenoids in Age Related Eye Disease Study MP macular pigment Middle Aged Scavenger Receptors Class B eye diseases Dietary Supplements supplementation Z zeaxanthin Female sense organs Retinal Pigments ATP Binding Cassette Transporter 1 |
| Zdroj: | Experimental Eye Research |
| ISSN: | 1096-0007 |
| Popis: | Supplementation with carotenoids is proposed to protect against age-related macular degeneration. There is, however, considerable variability in retinal macular pigment response, which may be due to underlying genetic variation. The purpose of this study was to determine whether genetic factors, which have been previously associated with cross-sectional macular pigment levels in the retina or serum lutein, also influence response to supplementation. To this end we conducted an association study in 310 subjects from the TwinsUK cohort between variants in 8 candidate genes and serum lutein and retinal macular pigment optical density (MPOD) levels before and after supplementation. Four variants were associated with MPOD response to supplementation (p Highlights • Four variants were associated with macular pigment response to supplementation. • We replicated associations between BMCO1 variants and lutein at baseline. • Carotenoids transport may affect macular response to supplementation. • Lipid metabolism may affect macular response to supplementation. |
| Databáze: | OpenAIRE |
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