| Autor: |
Andrei Ştefan, Săndulescu, Alex Emilian, Stepan, Claudiu, Mărgăritescu, Viorela, Enăchescu, George, Mitroi, Cristiana Eugenia, Simionescu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 63(1) |
| ISSN: |
2066-8279 |
| Popis: |
Alteration of the intercellular adhesion system plays an essential role in the initiation and progression of bladder carcinomas. We followed the immunoexpression of adhesion molecules, E-cadherin, β-catenin and Claudin-1, in relation to the histopathological grade and the pT category in a number of 50 urothelial carcinomas of the bladder, based on a final staining score (FSS), calculated on the basis of reaction intensity and labeled cells number. E-cadherin immunoexpression was identified in the membrane of tumor cells, low FSS being associated with invasive high-grade carcinomas. β-catenin reactions were membranous in the case of low-grade noninvasive carcinomas and predominantly cytoplasmic and nuclear in the case of high-grade invasive ones, for which high FSS were associated. Claudin-1 was identified at the membrane level, the high FSS values being more frequent in the case of high-grade invasive carcinomas, although there were no significant statistical associations. Loss of E-cadherin expression and the associated positive linear relation of β-catenin and Claudin-1 indicate the usefulness of the analyzed markers in identifying the invasive aggressive phenotype of urothelial bladder carcinomas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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