On the mechanism of antiaggregatory effect of myricetin

Autor: J, Robak, R, Korbut, F, Shridi, J, Swies, H, Rzadkowska-Bodalska
Rok vydání: 1988
Předmět:
Zdroj: Polish journal of pharmacology and pharmacy. 40(3)
ISSN: 0301-0244
Popis: Myricetin at a dose of 3.6 micrograms/kg iv was found to inhibit the cat blood platelet aggregation in vivo. It disaggregated platelet thrombi in vitro at a concentration of 60 nM. This flavonoid bound to platelet membranes and prevented prostacyclin synthase against oxygen free radicals owing to its antioxidant properties. Myricetin inhibited soybean lipoxygenase when linoleic acid was used as a substrate.
Databáze: OpenAIRE