Atrial Fibrillation After Coronary Artery Bypass Surgery: Can Ivabradine Reduce Its Occurrence?

Autor:	Zainab, Abdel-Salam, Wail, Nammas
Rok vydání:	2016
Předmět:	Male Time Factors Action Potentials Pilot Projects Coronary Artery Disease Benzazepines Middle Aged Adrenergic beta-1 Receptor Antagonists Drug Administration Schedule Treatment Outcome Elective Surgical Procedures Heart Rate Atrial Fibrillation Electrocardiography Ambulatory Bisoprolol Humans Drug Therapy Combination Egypt Female Ivabradine Prospective Studies Coronary Artery Bypass Anti-Arrhythmia Agents Aged
Zdroj:	Journal of cardiovascular electrophysiology. 27(6)
ISSN:	1540-8167
Popis:	We compared the efficacy of perioperative ivabradine, bisoprolol, or both for prevention of postoperative atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG).We enrolled 740 consecutive patients scheduled for elective CABG with/without valve surgery. Patients were assigned to 1 of 3 protocols: ivabradine given perioperatively (48 hours preoperatively, then 1 week postoperatively) 5 mg bid for 24 hours, then 7.5 mg bid thereafter in patients who can tolerate (group 1, n = 212); bisoprolol given perioperatively 5 mg bid (group 2, n = 288); or both drugs given perioperatively (ivabradine as before + bisoprolol 5 mg once daily) (group 3, n = 240). Cardiac rhythm was continuously monitored for 15 days postoperatively by ambulatory event recorder. Clinical follow-up for the occurrence of arrhythmias was performed for the next 15 days. The primary endpoint was the incidence of AF at 30-day follow-up. Mean age was 56.5 ± 8.9 years (30.5% females). All patients completed 30-day follow-up. AF occurred in 10.4%. The 3 groups were matched for most baseline characteristics, echocardiographic and angiographic data (P0.05 for all). The incidence of AF was significantly lower in group 3 (4.2%), compared with group 1 (15.5%), and group 2 (12.2%), (P0.001 both). The duration of stay in the intensive care unit was shorter in group 3 versus group 1 and 2 (P0.001 both).In patients undergoing elective CABG, adding ivabradine to β-blockers during the perioperative period was associated with reduced incidence of AF at 30-day follow-up, compared with either medication alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::027083d7002fcc12e6f8f919799ba620 https://pubmed.ncbi.nlm.nih.gov/27006322 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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