Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome
| Autor: | Werner, Dammermann, Valentin, Mihajlov, Barbara, Middendorf, Alexander, Mellmann, Helge, Karch, Stefan, Lüth, Sebastian, Ullrich |
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| Rok vydání: | 2017 |
| Předmět: |
Fever
Plasmapheresis Antibodies Bacterial Shiga Toxin 2 Escherichia coli O104 Anti-Bacterial Agents Immunoglobulin M Predictive Value of Tests Immunoglobulin G Superinfection Hemolytic-Uremic Syndrome Humans Nervous System Diseases Acute-Phase Reaction Biomarkers Escherichia coli Infections Retrospective Studies |
| Zdroj: | Journal of gastroenterology and hepatology. 33(7) |
| ISSN: | 1440-1746 |
| Popis: | An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non-HUS: n = 9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.Anti-Stx2 antibodies seem to accompany or even precede HUS development. |
| Databáze: | OpenAIRE |
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