| Autor: |
D M, Lomtadze, I B, Tsorin, E Iu, Chirkova, G G, Chichkanov |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Farmakologiia i toksikologiia. 54(3) |
| ISSN: |
0014-8318 |
| Popis: |
The experiments on different species of animals (mice, cats) showed the lack of parallelism between the antihypoxic and anti-ischemic effects of pharmacological agents. Of four studied antihypoxic agents (lithium oxybutyrate, piracetam, glyo-6, a derivative of pyrimidine S-207) only GABA derivatives showed an increase of the lactate/pyruvate ratio in the blood of the venous sinus under occlusion of the coronary artery and consequently possessed the anti-ischemic properties. Such difference in the effects of the antihypoxic agents on the myocardium was determined to a certain degree by their different influences on the collateral coronary blood circulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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