| Autor: |
B, Gjata, C, Hannoun, H J, Boulouis, T, Neway, C, Pilet |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 317(3) |
| ISSN: |
0764-4469 |
| Popis: |
Mice injected intraperitoneally with 2.5 or 25 mg/kg of pGPL-Mc, before, during or after the administration of a monovalent inactivated influenza vaccine (8 IU of A/New Jersey/X53), exhibited significantly very high haemagglutination inhibition (HI) antibody titers (up to 8 fold) as compared to vaccine controls. Treatment with pGPL-Mc has increased the protective effect of the vaccine by completely abolishing, in certain treatment groups, the onset of symptoms of disease and mortality after a lethal challenge with 5 LD50 of A/PR/8/34 virus, 60 days after the first vaccination. Moreover, the development of visible pulmonary lesions significantly decreased in surviving vaccinated mice treated with 25 mg/kg of pGPL-Mc on day D0. These results suggest that pGPL-Mc is a potent adjuvant to the immunogenic and protective effect of inactivated influenza vaccines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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