| Autor: |
Hideaki, Sato, Takayuki, Ii, Shota, Hotchi, KengWee, Goh, Naoki, Rikiyama, Ami, Sato, Naoki, Akishige, Takashi, Kokumai, Yasutaka, Aoki, Daisuke, Kikuchi, Hideaki, Yamanami |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 48(13) |
| ISSN: |
0385-0684 |
| Popis: |
A 76-year-old male underwent distal gastrectomy for gastric cancer and pathological findings showed Stage Ⅳ(T4a, N3a, M1, H0, P0, CY1)with HER2 positivity. He received chemotherapy with S-1 and oxaliplatin(SOX)plus trastuzumab and no disease progression was shown. However, because of Grade 3 adverse skin effects to S-1, he could not continue with the regimen. He switched to a regimen of ramucirumab plus paclitaxel, followed by nivolumab, and later irinotecan. However, the disease progressed and multiple lung metastases as well as a left adrenal metastasis appeared. Fifth-line chemotherapy with trastuzumab was administered. After 4 courses, the lung metastases reduced and the left adrenal metastasis shrank from 46 mm to 33 mm. These results were consistent with a partial response on the Response Evaluation Criteria in Solid Tumors. In addition, CEA and CA19-9 also decreased significantly. Unfortunately, after 10 courses, the patient's disease progressed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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