| Autor: |
Nicholas, Buss, Patricia, Ryan, Todd, Baughman, Denis, Roy, Claire, Patterson, Carolyn, Gordon, Rakesh, Dixit |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Journal of applied toxicology : JAT. 38(10) |
| ISSN: |
1099-1263 |
| Popis: |
Exenatide, a glucagon-like peptide-1 receptor agonist was originally developed as either a twice daily or once weekly injectable therapeutic for patients with type 2 diabetes. Exenatide QW suspension was developed for use with an autoinjector device, in which the microspheres are suspended in Miglyol 812, a mixture of medium chain triglycerides (MCTs). MCTs are a class of lipids whose fatty acid chains contain from six to 12 carbon atoms (medium chain fatty acids or MCFAs). While MCTs are edible oils present in many foods, including foodstuffs containing coconut and palm kernel oils, limited information is available regarding the oral and subcutaneous bioavailability of MCTs as well as safety following subcutaneous injection. These studies were designed to investigate the non-clinical pharmacokinetics and safety of MCTs. In a single dose pharmacokinetic study, MCFAs were rapidly detected in the plasma of rats following oral administration of either Miglyol 812 or tricaprylin at doses of 10 or 9.48 g kg |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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