| Autor: |
Piotr, Lisowski, Jolanta, Małyszko, Ryszard, Jackowsk, Michał, Myśliwiec, Anna, Lisowska, Tomasz, Łapiński, Krystyna, Pawlak, Tomasz, Hirnle |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Kardiologia polska. 60(2) |
| ISSN: |
0022-9032 |
| Popis: |
Atherogenesis is triggered by functional or structural endothelial injury which leads to humoral and secretion alterations. The haemostatic system plays a significant role in the development of atherosclerosis and its complications, especially acute coronary syndromes.To assess the effects of coronary artery by-pass grafting (CABG) on some haemostatic factors in patients with stable coronary artery disease (CAD).The study group consisted of 45 patients (11 females, 34 males, mean age 60.4+/-9.4 years, range 35-75 years). Endothelial function marker - von Willebrand factor (vWF), and thrombin generation parameters - thrombin-antithrombin complexes (TAT) and prothrombin fragments - F1+2 were measured before as well as 3 days, 7 days and 3 months after CABG. The control group consisted of 33 healthy volunteers (17 females, 16 males, mean age 48.8+/-17.2 years).Serum concentration of vWF as well as TAT and F1+2 levels were significantly higher in the CABG group than in controls. Compared with baseline values, the vWF levels were significantly higher 3 and 7 days after CABG.There is a hypercoagulability state in patients with CAD who undergo CABG. The use of extracorporeal circulation causes a significant increase in the vWF level which suggests a marked endothelial injury caused by CABG procedure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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