| Autor: |
Zheng, Su, Lingtong, Kong, Yong, Dai, Jin, Tang, Jiawei, Mei, Zhengzheng, Qian, Yuanyuan, Ma, Qianming, Li, Shenghong, Ju, Jiaxing, Wang, Wenpei, Fan, Chen, Zhu |
| Rok vydání: |
2022 |
| Zdroj: |
Science advances. 8(14) |
| ISSN: |
2375-2548 |
| Popis: |
There is an increasingly growing demand for nonantibiotic strategies to overcome drug resistance in bacterial biofilm infections. Here, a novel "gas-sensitized hyperthermia" strategy is proposed for appreciable bacteria killing by the smart design of a metal-organic framework (MOF)-sealed Prussian blue-based nanocarrier (MSDG). Once the biofilm microenvironment (BME) is reached, the acidity-activated MOF degradation allows the release of diallyl trisulfide and subsequent glutathione-responsive generation of hydrogen sulfide (H |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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