[Immunology in the medical practice.XXXII. Transplantation of autologous hematopoietic stem cells for treatment of refractory auto-immune diseases; preliminary favorable results with 35 patients]
| Autor: | A M, Vlieger, F H, van den Hoogen, D M, Brinkman, J M, van Laar, M, Schipperus, A A, Kruize, N M, Wulffraat |
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| Jazyk: | Dutch; Flemish |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Multiple Sclerosis Scleroderma Systemic Transplantation Conditioning Adolescent Remission Induction Drug Resistance Hematopoietic Stem Cell Transplantation Infant Newborn Pilot Projects Syndrome Macrophage Activation Transplantation Autologous Autoimmune Diseases Arthritis Rheumatoid Treatment Outcome Child Preschool Humans Lupus Erythematosus Systemic Female Child Netherlands |
| Zdroj: | Nederlands tijdschrift voor geneeskunde. 144(33) |
| ISSN: | 0028-2162 |
| Popis: | The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion. |
| Databáze: | OpenAIRE |
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