| Autor: |
K, Trnavský, J, Gatterová, M, Lindusková, Z, Pelisková |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Zeitschrift fur Rheumatologie. 52(5) |
| ISSN: |
0340-1855 |
| Popis: |
The aim of the study was to compare the efficacy of hydroxychloroquine (HCQ) alone and in combination with methotrexate (MTX) in a randomized placebo-controlled study lasting 6 months. Forty patients with rheumatoid arthritis participated in the study and were randomly assigned to two groups--20 patients were treated with HCQ (200 mg daily) and placebo, 20 patients with HCQ and MTX (7.5 mg) once a week. Patients were assessed at regular intervals of 1 month up to 6 months using six clinical and five laboratory tests and one radiological measure. All six clinical variables and two laboratory variables were favorably influenced by combination therapy during the 6-month period. HCQ alone significantly influenced only three clinical variables and none of the laboratory parameters. There was a greater number of patients without radiological progression in the combination group. There was one drop-out in combination group due to general allergic reaction; otherwise the treatment was well tolerated. The results suggest that a combination of HCQ and MTX is more potent than HCQ alone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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