The efficacy of EBER in situ hybridization (ISH) stain in PTLD (malignant diffuse large B-cell lymphoma) about 4 years after ABO-incompatible kidney transplantation: a case report
| Autor: | Nose, Kazuhiro, Oki, Takashi, banno, Eri, Sugimoto, Koichi, Nishioka, Tsukasa, Ochiai, Ken, Maekura, Syunji |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Epstein-Barr Virus Infections Herpesvirus 4 Human Time Factors Biopsy Case Report Middle Aged Immunohistochemistry Kidney Transplantation ABO Blood-Group System Fatal Outcome Treatment Outcome Risk Factors hemic and lymphatic diseases Histocompatibility Biomarkers Tumor Humans RNA Viral Autopsy Lymphoma Large B-Cell Diffuse Immunosuppressive Agents In Situ Hybridization |
| Popis: | Post-transplant lymphoproliferative disease (PTLD) is a well-known late complication of organ transplantation which incidence has increased after the introduction of more powerful immunosuppressive agents. A 58-year-old man performed ABO-incompatible living kidney transplantation in June, 2008. At 3 years and 9 months after the transplantation, the patient complained of general fatigue and dyspnea and was hospitalized with renal dysfunction. The clinical data in hospital showed acute rejection, but soluble IL-II exceeded 21700U/ml, and HE staining kidney graft showed a massive infiltration of atypical lymphocytes. Atypical lymphocytes were positive for L-26 and negative for CD3 immunochemical stein, and the EBER in situ hybridization stain for EBV was negative in renal graft. We diagnosed diffuse large B-cell lymphoma in the kidney graft. However, he died due to multiple organ failure (MOF). We described a fatal case of diffuse large B-cell lymphoma without EBV infection occurring 3 years 9 months after ABO-incompatible kidney transplantation. Unfortunately, post-mortem autopsy using EBER-ISH stain does not show whether EB virus infection was a cause. |
| Databáze: | OpenAIRE |
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