TβRIII is induced by TCR signaling and downregulated in FoxP3
| Autor: | Sandra, Ortega-Francisco, Marisol, de la Fuente-Granada, Evelyn K, Alvarez Salazar, Lizbeth Airais, Bolaños-Castro, Gabriela, Fonseca-Camarillo, Roxana, Olguin-Alor, Germán R, Alemán-Muench, Fernando, López-Casillas, Chander, Raman, Eduardo A, García-Zepeda, Gloria, Soldevila |
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| Rok vydání: | 2017 |
| Předmět: |
Receptors
Antigen T-Cell Down-Regulation Forkhead Transcription Factors Mice Transgenic In Vitro Techniques Lymphocyte Activation T-Lymphocytes Regulatory Up-Regulation Mice Inbred C57BL Mice Animals Humans Proteoglycans Immunologic Memory Receptors Transforming Growth Factor beta Signal Transduction |
| Zdroj: | Biochemical and biophysical research communications. 494(1-2) |
| ISSN: | 1090-2104 |
| Popis: | TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive. Here we describe a detailed characterization of TβRIII expression in murine and human lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naïve and central memory T cells. TβRIII was upregulated after TCR stimulation, in parallel to other early activation markers. In contrast, natural and induced Tregs downregulated TβRIII in association with FoxP3 upregulation. Finally, anti-TβRIII blocking experiments demonstrated that TβRIII promotes TGFβ-dependent iTreg conversion in vitro, and suggest that this co-receptor may be involved in modulating peripheral T cell tolerance and could be considered as a potential target to boost T cell immune responses. |
| Databáze: | OpenAIRE |
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