[Cytostatic effects of bifolar and chlofiden. Effect on protein synthesis and cell cycle]

Autor: N I, Sharykina, T A, Bukhtiarova, I G, Kudriavtseva, G P, Pavlovskaia
Rok vydání: 2005
Předmět:
Zdroj: Ukrains'kyi biokhimichnyi zhurnal (1999 ). 76(1)
Popis: Study of influence of new antitumor preparations bifolar and chlofiden on rat liver protein biosynthesis in vivo and on sarcoma-45 in vitro was carried out using labeled precursor 3H-leucine. It was shown that the preparations inhibited protein synthesis in normal and malignant tissues. Mitotic cycle and its phases were investigated with 3H-tymedin. It was established that bifolar influenced all the phases of mitotic cycle and the sensitive phases of the mitosis itself, which are connected with the redistribution of genetic material.
Databáze: OpenAIRE