Immunomodulation using bacterial enterotoxins
| Autor: | C P, Simmons, M, Ghaem-Magami, L, Petrovska, L, Lopes, B M, Chain, N A, Williams, G, Dougan |
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| Rok vydání: | 2001 |
| Předmět: |
Models
Molecular Cholera Toxin Escherichia coli Proteins T-Lymphocytes Bacterial Toxins Antigen-Presenting Cells CD8-Positive T-Lymphocytes Enterotoxins Mice Protein Subunits Structure-Activity Relationship Adjuvants Immunologic Virus Diseases Animals Humans Poly(ADP-ribose) Polymerases Immunity Mucosal |
| Zdroj: | Scandinavian journal of immunology. 53(3) |
| ISSN: | 0300-9475 |
| Popis: | Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development. |
| Databáze: | OpenAIRE |
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