Liver Transplantation for Metastatic Neuroendocrine Tumors: Outcomes and Prognostic Variables
| Autor: | SHER, LINDA S., LEVI, DAVID M., WECSLER, JULIE S., LO, MARY, PETROVIC, LYDIA M., GROSHEN, SUSAN, JI, LINGYUN, USO, TERESA DIAGO, TECTOR, A. JOSEPH, HAMILTON, ANN S., MARSH, J. WALLIS, SCHWARTZ, MYRON E. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent Kaplan-Meier Estimate Risk Assessment Article Pancreaticoduodenectomy Pancreatectomy Predictive Value of Tests Risk Factors Humans Aged Patient Selection Liver Neoplasms Middle Aged Prognosis United States Liver Transplantation Intestines Survival Rate Neuroendocrine Tumors Treatment Outcome Splenectomy Female Neoplasm Recurrence Local Follow-Up Studies |
| Zdroj: | J Surg Oncol |
| Popis: | BACKGROUND: Patient selection for liver transplantation for metastatic neuroendocrine tumors remains a topic of debate. There is no established MELD exception, making it difficult to obtain donor organs. METHODS: A multicenter database was created assessing outcomes for liver and multivisceral transplantation for metastatic neuroendocrine tumors and identifying prognostic factors for survival. Demographic, transplant, primary tumor site and management, pathology, recurrent disease and survival data were collected and analyzed. Survival probabilities were calculated using the Kaplan–Meier method. RESULTS: Analysis included 85 patients who underwent liver transplantation November 1988–January 2012 at 28 centers. One, three, and five-year patient survival rates were 83%, 60%, and 52%, respectively; 40 of 85 patients died, with 20 of 40 deaths due to recurrent disease. In univariate analyses, the following were predictors of poor prognosis: large vessel invasion (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|