| Autor: |
R N, Aliautdin, V E, Petrov, K, Langer, A, Berthold, J, Kreuter, D A, Kharkevich |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 61(1) |
| ISSN: |
0869-2092 |
| Popis: |
The possibility of using polysorbate 80-coated nanoparticles for the delivery of the water insoluble opioid (lyonist loperamide across the blood-brain barrier was investigated. The analgesic effect after i.v. injection of the preparations was used as the indication of drug transport through this barrier. Intravenous injection of the particulate formulation resulted in a long and significant analgesic effect. A polysorbate 80 loperamide solution induced a much less pronounced and very short analgesia. Uncoated nanoparticles loaded with loperamide were unable to produce analgesia. Polysorbate 80-coated PBCA nanoparticles loaded with loperamide led to the transport of loperamide to the brain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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