Multimodal assessment of orbital immune cell infiltration and tissue remodeling during development of graves disease by

Autor:	Ulrich, Flögel, Anke, Schlüter, Christoph, Jacoby, Sebastian, Temme, J Paul, Banga, Anja, Eckstein, Jürgen, Schrader, Utta, Berchner-Pfannschmidt
Rok vydání:	2017
Předmět:	Graves Ophthalmopathy Inflammation Disease Models Animal Mice Image Processing Computer-Assisted Animals Edema Receptors Thyrotropin Eye Magnetic Resonance Imaging
Zdroj:	Magnetic resonance in medicine. 80(2)
ISSN:	1522-2594
Popis:	To evaluate key molecular and cellular features of Graves orbitopathy (GO) by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling.To this end, we utilized a murine model of GO induced by immunization with a human thyroid-stimulating hormone receptor A-subunit plasmid. Altogether, 52 mice were used: 27 GOs and 25 controls (Ctrl) immunized with β-galactasidose plasmid. From these, 17 GO and 12 Ctrl mice were subjected to multimodal MRI at 9.4T, whereas 23 mice only underwent histology. Beyond anatomical hydrogen-1 (The present approach permits the comprehensive characterization of orbital tissue and holds the potential for accurate GO diagnosis in the clinical setting. Magn Reson Med 80:711-718, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::00970cdc08e40f574d1ae70ac67918c2 https://pubmed.ncbi.nlm.nih.gov/29377287 Zobrazit plný text záznamu Plný text