| Autor: |
Dominguez, Lorena Lopez, Bourdon, Celine, Borges, Maria Carolina, Rodrigues, Luciana Tovo, Santos, Ina S, Matijasevich, Alicia, Barros, Aluisio JD, Bandsma, Robert HJ, Comelli, Elena M |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Curr Dev Nutr |
| Popis: |
OBJECTIVES: The relationship between gut microbiota and growth during infancy has been substantiated, but whether this stands true in later childhood is under investigation. We used a new clustering methodology that improves interpretability of later childhood growth patterns. Three distinct patterns were identified (Increasing, Stable, Declining) for BMI-for-age (BMIZ) and height-for-age Z-scores (HAZ) in a birth cohort of 4231 Brazilian children. Here, we investigate the association between these growth patterns and gut microbiota diversity in late childhood. METHODS: We sampled 337 children from the 2004 Pelotas birth cohort (Brazil) grouped into Increasing (n = 78; 68), Stable (n = 161; 170), or Declining (n = 98; 99) patterns for BMIZ and HAZ, respectively. Feces and anthropometrics were collected at age 13 years. The fecal microbiota was analyzed via Illumina MiSeq (16S rRNA V3-V4 region) and the UNOISE pipeline. Alpha (Kruskal-Wallis) and beta (permutational multivariate analysis of variance) diversity were assessed in QIIME2. RESULTS: The microbiota of children in the BMIZ Increasing pattern had lower richness and evenness compared to those in the Stable or Decreasing patterns (Chao1, q |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
