P16-S Database Search of High Mass Resolution Data

Autor: Sadygov, R. G., Zabrouskov, V.
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Popis: The work describes modifications to and application of Sequest database search algorithms to identify peptides from their high mass accuracy tandem mass spectra. We show the technical problems encountered when attempting to use high mass accuracy data with the original Sequest algorithm. To overcome the problems, modifications have been made to the algorithm. The modifications are such that the results from the unmodified and modified algorithms are the same for the unit mass accuracy data. The work presents advantages in terms of the speed and reduced memory requirements of the modified algorithm.
Databáze: OpenAIRE