| Autor: |
Xu, Bin, Niu, Xiao-Bing, Wang, Zi-Dun, Cheng, Wei, Tong, Na, Mi, Yuan-Yuan, Min, Zhi-Chao, Tao, Jun, Li, Peng-Chao, Zhang, Wei, Wu, Hong-Fei, Zhang, Zheng-Dong, Wang, Zeng-Jun, Hua, Li-Xin, Feng, Ning-Han, Wang, Xin-Ru |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Translational Andrology and Urology |
| ISSN: |
2223-4691 |
| Popis: |
Interleukin-6 (IL-6) is a multifunctional cytokine involved in different physiologic and pathophysiologic processes and plays important roles in the etiology of cancer. The -174G[C polymorphism of the IL-6 gene influencesIL-6 transcription and has been implicated in cancer risk. However, published data have been conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 29,377 cancer cases and 37,739 controls from 50 published cases—control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between -174G> C polymorphism and cancer risk. Overall meta-analysis indicated that no association was found between -174G>C genotypes and cancer risk. However, the positive association was found in bladder cancer (OR =4.33, 95% CI: 1.93-9.71 for CC vs. GC, OR =2.81, 95% CI: 1.39-5.68 for CC vs. GG, and OR =2.19, 95% CI: 1.32-3.64 for CC vs. GG/GC), and among Asians (OR =2.08, 95% CI: 1.07-4.06 for CC vs. GG, and OR =2.20, 95% CI: 1.02-4.74 for CC vs. GG/GC) and Africans (OR =1.61, 95% CI: 1.07-2.42 for GC vs. GG). This meta-analysis showed the evidence that the -174G>C of the IL-6 gene was a low-penetrance susceptibility gene for bladder cancer. Further larger, preferably prospective studies are needed to confirm this relationship. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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