Linezolid: a Promising Agent for the Treatment of Multiple and Extensively Drug-Resistant Tuberculosis

Autor:	Fermeli, Dionysia, Marantos, Theodoros, Liarakos, Alexandros-Leonidas, Panayiotakopoulos, George, Dedes, Vasileios, PANOUTSOPOULOS, GEORGIOS
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	efficacy multi-drug resistant TB adverse effects extensively drug-resistant TB linezolid
Zdroj:	Folia Medica 62(3): 444-452
ISSN:	1314-2143 0204-8043
DOI:	10.3897/folmed.62.e48742
Popis:	Tuberculosis is a severe, infectious disease caused by Mycobacterium tuberculosis. The aim of this review was to present the efficacy of linezolid as an agent against multidrug and extensively drug-resistant tuberculosis as gathered from many recent research studies. Linezolid seems to have strongly the potential of being used as an anti-tuberculosis agent because it blocks bacterial ribosomal protein synthesis. Nevertheless caution is required because of the adverse effects it causes, especially when the linezolid daily dosage exceeds 600 mg. The most severe adverse effects include anemia, peripheral neuropathy, optic neuropathy and thrombocytopenia. Still, more trials and research need to be done in order to gather more information and value the cost-benefit dosage of the treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pensoft_____::ad7070383436e735bed0e9ef8209fd46 https://doi.org/10.3897/folmed.62.e48742 Zobrazit plný text záznamu