| Autor: |
Bijleveld, Yuma A, Mathôt, Ron A A, van der Lee, Johanna H, Groenendaal, Floris, Dijk, Peter H, van Heijst, Arno, Simons, Sinno H P, Dijkman, Koen P, van Straaten, Henrica L M, Rijken, Monique, Zonnenberg, Inge A, Cools, Filip, Zecic, Alexandra, Nuytemans, Debbie H G M, van Kaam, Anton H, de Haan, Timo R, PharmaCool study group |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
The pharmacokinetics (PK) of amoxicillin in asphyxiated newborns undergoing moderate hypothermia were quantified using prospective data (N = 125). The population PK was described by a 2-compartment model with a priori birthweight (BW) based allometric scaling. Significant correlations were observed between clearance (Cl) and postnatal age (PNA), gestational age (GA), body temperature (TEMP), and urine output (UO). For a typical patient with GA 40 weeks, BW 3,000 g, 2 days PNA (i.e., TEMP 33.5°C), and normal UO, Cl was 0.26 L/h (interindividual variability (IIV) 41.9%) and volume of distribution of the central compartment was 0.34 L/kg (IIV of 114.6%). For this patient, Cl increased to 0.41 L/h at PNA 5 days and TEMP 37.0°C. The respective contributions of both covariates were 23% and 27%. Based on Monte Carlo simulations we recommend 50 and 75 mg/kg/24h amoxicillin in three doses for patients with GA 36-37 and 38-42 weeks, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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