| Autor: |
Oeckl, P., Anderl-Straub, S., Lauer, M., Levin, J., Ludolph, A. C., Prudlo, J., Schneider, A., Schroeter, M., Semler, E., Steinacker, P., Uttner, I., Wiltfang, J., Diehl-Schmid, J., Danek, A., Otto, M., von Arnim, C. A. F., Fassbender, K., Feneberg, E., Fließbach, Klaus, Forstl, H., Jahn, H., Landwehrmeyer, B. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Journal of neurochemistry 138(Supplement 1), 355 (2016). |
| Popis: |
Primary progressive aphasias (PPA), including the semanticvariant (svPPA), non-fluent variant (nfvPPA) and logopenic variant(lvPPA), are neurodegenerative diseases characterized by a pro-gressive decline in speach. Neuropathologically, svPPA and nfvPPAare assigned to frontotemporal dementia whereas lvPPA is mainlyassociated with Alzheimer0s disease (AD). Differential diagnosis ofPPAs is based on clinical symptoms and objective neurochemicalbiomarkers are highly appreciated to improve diagnostic accuracy.Here, we investigated a panel of biomarker candidates in cere-brospinal fluid (CSF) of PPA patients (n = 66) in a multicentercohort from the German FTLD consortium.There were no significant differences in CSF concentrations ofubiquitin (Kruskal-Wallis test, p = 0.50), progranulin (p = 0.12),Tau (p = 0.12) and pTau181 (p = 0.07) between PPAs. Ab42 wassignificantly reduced in lvPPA versus nfvPPA (p < 0.05) but notsvPPA and there was a great overlap between groups. The ratio ofthe AD biomarkers Ab42/pTau181 significantly differentiatedlvPPA from nfvPPA (p < 0.01) and svPPA (p < 0.05) and showeda sensitivity and specificity of 91.7% and 64.3% (lvPPA vs.nfv+svPPA). Neurofilament light chain (NfL) was significantlylower in lvPPA compared with nfvPPA (p < 0.01) and svPPA(p < 0.001) and sensitivity and specificity was 70.8% and 92.9%.Combination of NfL and AD biomarkers in the term Ab42*NfL/pTau181 improved diagnostic accuracy for the differentiation oflvPPA from nfvPPA and svPPA patients (sensitivity 87.5% andspecificity 85.7%). The phosphorylated neurofilament heavy chain(pNFH) was significantly increased in nfvPPA vs. svPPA (p < 0.05)and lvPPA (p < 0.01) and showed a sensitivity and specificity of80.0% and 64.3% to discriminate nfvPPA and svPPA.In conclusion, the combination of the AD biomarkers Ab42 andpTau181 with NfL is promising in the discrimination of lvPPApatients from nfvPPA and svPPA. CSF pNfH concentrations may assist in the differential diagnosis of nfvPPA and svPPA althoughadditional biomarkers are appreciated to increase sensitivity andspecificity of pNfH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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