| Autor: |
ToVinh, Michael, Hörr, Gregor, Rieke, Gereon J, Wilhelm, Christoph, Schmitt, Vanessa, Möhl, Christoph, Aghabeig, Mansoureh, Schwarze-Zander, Carolynne, Boesecke, Christoph, van Bremen, Kathrin, Wasmuth, Jan-Christian, Strassburg, Christian P, Dobrikova, Kristiyana, Rockstroh, Jürgen K, Spengler, Ulrich, Krämer, Benjamin, Nattermann, Jacob, Gotter, Christina, Rommel, Clemens, Hoffmeister, Christoph, Raabe, Jan, Kaiser, Kim M, Finnemann, Claudia, Bischoff, Jenny |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The journal of infectious diseases 226(5), 901-906 (2022). doi:10.1093/infdis/jiac103 |
| DOI: |
10.1093/infdis/jiac103 |
| Popis: |
HIV infection is associated with impaired NK cell activity, which is only incompletely restored under antiretroviral therapy. Analysing the bioenergetics profiles of oxygen consumption, we observed several parameters were significantly reduced in HIV(+) NK cells, indicating a mitochondrial defect. Accordingly, we found HIV(+) CD56 bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with IFNγ production of NK cells. Finally, we demonstrated that stimulation of HIV(+) NK cells with MitoTEMPO, mitochondria-targeting antioxidant, significantly improved IFNγ production. In conclusion, we identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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