The effect of glutamate and aspartate on myocardial protection at cardiopulmonary bypass

Autor: Özcan, Vefa, Beşo?ul, Y., Tünerir, B., Dernek, S., Erden, T., Özdemir, C., Ünal, O.
Jazyk: turečtina
Rok vydání: 2004
Předmět:
Male
age distribution
cigarette smoking
postoperative period
magnesium sulfate
dose response
gender
Creatine Kinase
MB Form
preoperative care
glucose
Coronary Artery Bypass
Cardioplegic Solutions
Creatine Kinase
time
coronary artery bypass surgery
clinical article
Cardiopulmonary bypass
potassium
drug effect
article
Middle Aged
inotropic agent
defibrillation
Troponin
isotonic solution
Isoenzymes
Treatment Outcome
creatine kinase MB
Cardiovascular Diseases
diabetes mellitus
Heart Arrest
Induced
blood sampling
Female
Glutamate
glutamic acid
aorta balloon
hypertension
heart infarction
bicarbonate
Myocardial Reperfusion Injury
heart protection
Student t test
troponin I
Humans
human
preoperative period
Myocardial protection
Aspartic Acid
medical documentation
aorta clamping
citric acid
mitral valve replacement
crystalloid
elective surgery
Aspartate
aorta valve replacement
cardioplegia
measurement
chi square test
Popis: Objective: To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass. Material and Methods: Thirty-four patients who were electively undergone open heart surgery at Osmangazi University Faculty of Medicine, thoracic and cardiovascular surgery department, between March 2001 and May 2001 were included in this study. The patients were divided in two groups, each consisting of 17 patients. In group 1 coronary artery bypass surgery (CABG) was performed in 11 patients, mitral valve replacement (MVR) in 3 patients, aortic valve replacement (AVR) in 1 patient and AVR and MVR in 2 patients. While in group 2 CABG was performed in 13 patients and MVR was done in 4 patients. Group 1 patients received antegrade glutamat and aspartat (15 mmol/L) enriched cold crystalloid cardioplegia and group 2 patients were given cold crystalloid cardioplegia by antegrade route. Age, gender, diabetes mellitus, hypertension, preoperative myocardial infarction, smoking, ejection fraction, aortic cross-clamp time, need to defibrillation, inotropic support, and intraaortic balloon pump were recorded. The levels of cardiac troponin I (cTI) and creatine kinase myocardial band fraction (CK-MB) were measured in arterial blood samples at five different times. Statistical analysis was performed using Student's t-test and Chi-square test. Results: There were no statistically significant differences in cTI and CK-MB values in blood samples taken at 5 different times pre and postoperatively between group 1 and group 2. Conclusion: It is concluded that glutamat and aspartat enriched cold crystalloid cardioplegia does not have any effect on myocardial protection.
Databáze: OpenAIRE
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