Influence of patient training on persistence, compliance, and tolerability of different dosing frequency regimens of bisphosphonate therapy: An observational study in Turkish patients with postmenopausal osteoporosis
| Autor: | Akarirmak Ü., Koçyiğit H., Eskiyurt N., Esmaeilzadeh S., Kuru O., Yalçinkaya E.Y., Peker O. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Turkey
drug administration patient education Drug Administration Schedule Medication Adherence Persistence Patient Education as Topic middle aged statistics and numerical data Bisphosphonate Training Humans controlled study bisphosphonic acid derivative human procedures Prospective Studies Dosing regimen Osteoporosis Postmenopausal bone density conservation agent Aged Bone Density Conservation Agents Diphosphonates medication compliance clinical trial female multicenter study randomized controlled trial Osteoporosis Compliance prospective study |
| Popis: | Objective: In our study, we aimed to evaluate the influence of training on compliance and persistence with bisphosphonate treatment given on a weekly vs. monthly basis in postmenopausal osteoporosis patients. Methods: A total of 979 patients with postmenopausal osteoporosis (mean age: 63.2 ± 7.2 years) were included in this national, multicenter, prospective non-interventional observational cohort registry study. Patients were randomized into training (n = 492, 50.3%, mean age: 63.4 ± 7.2 years) and control (n = 487, 49.7%, mean age: 63.0 ± 7.1 years) groups. Patients in each intervention group were given weekly (44.9% and 44.6% for training and control subjects, respectively) or monthly (55.1% and 55.4%, respectively) bisphosphonate regimens. After the initial visit, patients were followed up at three-month intervals throughout 12 months of treatment for evaluation of persistence, compliance and adverse events. Results: On average, 79.4% of the patients were persistent with the treatment with a mean of 350.4 days of duration during the 12-month follow-up period. The mean compliance in the compliant and fully compliant group remained at an average of 86.6%. No significant difference was detected between the training and control groups in terms of compliance and persistence. Significantly longer persistence (360.0 ± 89.0 vs. 345.0 ± 108.0 days; p = 0.035), higher percentage of persistent patients (83.4% vs. 74.2%; p = 0.012) and higher compliance rates (88.8% vs. 83.3%; p = 0.002) were noted in monthly regimen patients in comparison to those given weekly regimen. © 2016 Turkish Association of Orthopaedics and Traumatology. |
| Databáze: | OpenAIRE |
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