| Autor: |
Hahalis, G., Kremastinos, D. T., Terzis, G., Kalogeropoulos, A. P., Chrysanthopoulou, A., Karakantza, M., Kourakli, A., Adamopoulos, S., Tselepis, A. D., Grapsas, N., Siablis, D., Zournbos, N. C., Alexopoulos, D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
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| Popis: |
Background: Patients with beta-thalassemia major (beta-TM) demonstrate an increased incidence of vascular complications, which are thought to result from a procoagulant/proinflammatory environment. We investigated the arterial vasorelaxing capacity and sought for early carotid atherosclerosis and underlying pathophysiological correlates in these transfusion-dependent patients. Methods and results: The vasodilatory properties of the brachial artery and the carotid intima-media thickness (IMT) were examined with ultrasonography in 35 non-diabetic young adults with beta-TM (patient group) and 35 control subjects (control group). Among thalassemic patients, both endothelium-dependent (FMD) and -independent dilatation (FID) as well as their ratio was impaired, whereas IMT was increased (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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