Takayasu arteritis: epidemiological, clinical, and immunogenetic features in Greece
| Autor: | Karageorgaki, Z. T., Bertsias, G. K., Mavragani, C. P., Kritikos, H. D., Spyropoulou-Vlachou, M., Drosos, A. A., Boumpas, D. T., Moutsopoulos, H. M. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Glucocorticoids/therapeutic use Male Adolescent HLA-B Antigens/genetics/immunology Remission Induction Angiography Greece/epidemiology Comorbidity Middle Aged Immunogenetic Phenomena Genes MHC Class I/*immunology Takayasu Arteritis/epidemiology/genetics/immunology/therapy Young Adult Seroepidemiologic Studies Blood Vessels/pathology Humans Immunosuppressive Agents/therapeutic use Drug Therapy Combination Female Age of Onset Retrospective Studies |
| Popis: | OBJECTIVE: Takayasu arteritis (TA) is an uncommon disease with clinical heterogeneity across different ethnic groups. We aimed to evaluate the epidemiological, clinical, and immuno-genetic features of TA in Greece. METHODS: Demographic, clinical, laboratory, angiographic, and therapeutic data of 42 patients from 4 large referral centers were retrieved. Serology and Human Lymphocyte Antigen (HLA) typing was performed in 22 patients. RESULTS: We studied 37 women and 5 men with a median age of 31 years at disease onset. Median delay in diagnosis was 24 months and median follow-up was 47 months (range 0-178). Constitutional or musculoskeletal symptoms were present in 86%, especially early in the disease course. Vascular findings were universal with reduced or absent pulse being the most common manifestation (98%). Hypertension was frequent (78%). Extensive disease prevailed and stenotic lesions were more common than aneurysms (95% vs. 40%). Erythrocyte sedimentation rate and C-reactive protein showed modest correlation with disease activity. HLA-B52 was expressed by 37% of the patients vs. 2.4% of the controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|