Malignancies in beta-thalassemia patients: a single-center experience and a concise review of the literature
| Autor: | Benetatos, L., Alymara, V., Vassou, A., Bourantas, K. L. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hodgkin Disease/complications/diagnosis/therapy Lymphoma Non-Hodgkin/complications/diagnosis/drug therapy Humans Female Radiotherapy Adjuvant Seminoma/complications/diagnosis/therapy Middle Aged Testicular Neoplasms/complications/diagnosis/therapy Neoplasms/*complications beta-Thalassemia/*complications/diagnosis/*physiopathology/therapy |
| Popis: | Thalassemia represents the world's most common monogenic disease, characterized by absence of or decreased globin chain production. The lifespan of thalassemia patients has been extended as a result of current supportive treatment. We report three cases of cancer (non-Hodgkin lymphoma, Hodgkin disease, and seminoma) in thalassemic patients. Factors that may contribute to the pathogenesis of cancer seem to be infections and iron overload through mechanisms of oxidative damage; immunomodulation or coexistence of the two diseases may only be coincidental. Int J Lab Hematol |
| Databáze: | OpenAIRE |
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