Neutrophil and monocyte beta 2-integrin expression in trisomic fetuses
Autor: | Makrydimas, G., Thilaganathan, B., Plachouras, N., Nicolaides, K. H. |
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Jazyk: | angličtina |
Rok vydání: | 1995 |
Předmět: | |
Popis: | Flow cytometry was used to measure neutrophil and monocyte beta 2-integrin expression in fetuses with trisomy 18 (n = 7) and trisomy 21 (n = 7) at 20-25 weeks' gestation. The values were compared with those of 112 chromosomally normal fetuses. There were no significant differences in beta 2-integrin expression between normal and aneuploid fetuses. These findings demonstrate that in trisomies 21 and 18, alteration in beta 2-integrin expression is unlikely to contribute to the pathogenesis of immunological deficiencies that have been observed in these aneuploidies both prenatally and postnatally. Prenat Diagn |
Databáze: | OpenAIRE |
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