Palladium(II) complexes of 2-acetylpyridine N(4)-propyl, N(4)-dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity. Synthesis, spectral properties, antifungal and in vitro antitumor activity

Autor:	KovalaDemertzi, D., Domopoulou, A., Demertzis, M. A., Papageorgiou, A., West, D. X.
Jazyk:	angličtina
Rok vydání:	1997
Předmět:	n-4-dipropylthiosemicarbazones electrochemistry thiosemicarbazones n-4-diethylthiosemicarbazones new palladium complexes antitumor activity copper(ii) complexes 2-acetylpyridine thiosemicarbazones metal ion complexes redox behavior
Popis:	Some new palladium(II) complexes of 2-acetylpyridine N(4)-propyl-and N(4)dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity were described. The thiosemicarbazones and their palladium(II) complexes have been characterized by spectroscopic, and electrochemical techniques. The protonation constants of HAc4P K-a1 and K-a2, were determined by spectrophotometry and the pK(1a) and pK(a2) values are equal to 12.23 +/- 0.02 and 4.11 +/- 0.02. The antifungal properties and the effect selected compounds on DNA synthesis of P388 and L1210 cell cultures is reported. (C) 1997 Elsevier Science Ltd. Polyhedron
Databáze:	OpenAIRE
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