Cyclosporin-associated nephropathy in patients with autoimmune diseases
| Autor: | Mihatsch, M. J., Bach, J. F., Coovadia, H. M., Forre, O., Moutsopoulos, H. M., Drosos, A. A., Siamopoulos, K. C., Noel, L. H., Ramsaroop, R., Hallgren, R. |
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| Jazyk: | angličtina |
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Dose-Response Relationship Drug Kidney Diseases/*chemically induced Autoimmune Diseases/*drug therapy Middle Aged Kidney Function Tests Kidney Glomerulus/drug effects Nephritis Interstitial/chemically induced Humans Cyclosporins/*adverse effects/therapeutic use Female Kidney Tubules/drug effects Renal Artery/drug effects |
| Popis: | Renal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Ten biopsies were done before CyA, 10 biopsies after low-dose (less than 7.5 mg/kg/day, initial dose or mean daily dose within the first month, respectively), and 9 after high-dose (greater than 7.5 mg/kg/day) treatment. Definite chronic CyA nephrotoxicity (cyclosporin-associated arteriolopathy and/or interstitial fibrosis striped form with tubular atrophy) was only present in the initial high-dose group. In this group a significant serum creatinine increase was noted and 8 of the 9 patients were hypertensive. No significant correlation was found between the severity of morphologic lesions and the mean daily dose during total treatment, cumulative dose, and duration of therapy. The morphologic changes in the low-dose group did not differ from the control biopsy specimens before CyA treatment. Based on these results, it can be concluded that major nephrotoxicity can be avoided by initial low CyA doses. Klin Wochenschr |
| Databáze: | OpenAIRE |
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