The value of 99mTc-tetrofosmin brain SPECT in predicting survival in patients with glioblastoma multiforme
| Autor: | Alexiou, G. A., Tsiouris, S., Kyritsis, A. P., Fotakopoulos, G., Goussia, A., Voulgaris, S., Fotopoulos, A. D. |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Tomography Emission-Computed Single-Photon Organophosphorus Compounds/*diagnostic use Brain Neoplasms/*radionuclide imaging/*therapy Brain/*radionuclide imaging Kaplan-Meier Estimate Middle Aged Flow Cytometry Immunohistochemistry Survival Analysis Predictive Value of Tests Glioblastoma/*radionuclide imaging/*therapy Image Interpretation Computer-Assisted Humans Female Organotechnetium Compounds/*diagnostic use Karnofsky Performance Status Radiopharmaceuticals/*diagnostic use Ki-67 Antigen/analysis Aged |
| Popis: | (99m)Tc-tetrofosmin brain SPECT has been reported as a useful tool for the evaluation of glioma proliferation. In the present study, we set out to investigate the prognostic value of (99m)Tc-tetrofosmin brain SPECT in patients with glioblastoma multiforme. METHODS: We prospectively studied 18 patients (13 men, 5 women; mean age +/- SD, 60.8 +/- 7.79 y) who were operated on for glioblastoma multiforme. All patients underwent preoperative (99m)Tc-tetrofosmin brain SPECT, and surgical excision was performed within a week after SPECT. All patients received postoperative radiotherapy and chemotherapy. RESULTS: By calculating the lesion-to-normal (L/N) (99m)Tc-tetrofosmin uptake ratio, we found that patients with an L/N ratio of more than 4.7 had significantly worse survival than did patients with an L/N ratio of 4.7 or less. Furthermore, patients with a Karnofsky Performance Score more than 90 had a significantly better survival rate. Although patients with near-total tumor resection who were younger than 60 y survived longer, the difference did not reach statistical significance. In the multivariate analysis, (99m)Tc-tetrofosmin uptake and Karnofsky Performance Score were identified as factors with independent prognostic power. CONCLUSION: (99m)Tc-tetrofosmin brain SPECT may be an independent prognostic factor in patients with glioblastoma multiforme. Further larger studies are needed to verify these results. J Nucl Med |
| Databáze: | OpenAIRE |
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