Behavioral pharmacological properties of a novel cannabinoid 1',1'-dithiolane delta8-THC analog, AMG-3
| Autor: | Antoniou, K., Galanopoulos, A., Vlachou, S., Kourouli, T., Nahmias, V., Thermos, K., Panagis, G., Daifoti, Z., Marselos, M., Papahatjis, D., Spyraki, C. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
Behavior Animal/*drug effects/physiology Cell Membrane/drug effects/metabolism Piperidines/pharmacology Time Factors Dose-Response Relationship Drug Molecular Structure Pyrazoles/pharmacology Motor Activity/drug effects Cerebral Cortex/drug effects/metabolism Cyclohexanols/metabolism Binding Competitive/drug effects Cannabinoids/chemistry/*pharmacology Tritium Rats Rats Sprague-Dawley Receptor Cannabinoid CB1/agonists/antagonists & inhibitors/physiology Pain/physiopathology/prevention & control Animals Pain Measurement/methods Catalepsy/chemically induced/physiopathology |
| Popis: | Newly developed cannabinoids may hold the promise of the development of useful and safe drugs. This study aimed to investigate the behavioral effects of the novel 1',1'-dithiolane delta8-HC analogue AMG-3, a cannabinomimetic molecule with high affinity for CB1/CB2 receptors. This analog was chosen for its binding affinity to these receptors, which is higher than that reported for delta8-tetrahydrocannabinol (delta8-THC). Behavioral responses were assessed after the administration of AMG-3 (1, 2, 4, 8 mg/kg, i.p.) in the open field, on the bar test, on the hot plate and in the intracranial self-stimulation procedure. AMG-3 increased the reactivity time on the hot plate in a dose- and time-dependent manner, indicating a long-lasting analgesic effect (at least 24 h). The substance was found dose-dependently to decrease spontaneous motor activity and to induce catalepsy, particularly at the highest dose (8 mg/kg). AMG-3 did not affect the rewarding value of intracranial self-stimulation, except to increase the reward threshold at the highest dose (8 mg/kg). The effects of the highest dose of AMG-3 on spontaneous activity and on the self-stimulation paradigm were completely reversed by pre-treatment with the CB1 receptor antagonist AM-251. These findings indicate that the administration of AMG-3 to rats elicits a specific behavioral profile, most probably associated with the activation of CB1 receptors and without effects indicating abuse potential. Behav Pharmacol |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|