The platelet hyporesponsiveness to clopidogrel in acute coronary syndrome patients treated with 75 mg/day clopidogrel may be overcome within 1 month of treatment

Autor:	Kalantzi, K. I., Dimitriou, A. A., Goudevenos, J. A., Tselepis, A. D.
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	st-segment elevation clopidogrel disease leukocytes aspirin trial antiplatelet therapy acute coronary syndrome inflammation platelets stimulated phosphoprotein phosphorylation adenosine-diphosphate activation flow-cytometry thrombosis intervention
Popis:	Platelets are involved in thrombus formation and inflammation following vascular injury, while clopidogrel exerts antithrombotic and anti-inflammatory actions. We investigated various platelet-derived prothrombotic and proinflammatory mediators as well as the platelet aggregatory response in patients with acute coronary syndromes (ACS) receiving clopidogrel, as a function of the patient responsiveness to drug treatment. Blood samples were obtained from 40 patients with recent (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od_____10561::3c7edbcd23217a07b31c8dedc52cadc4 http://olympias.lib.uoi.gr/jspui/handle/123456789/9665 Zobrazit plný text záznamu