| Popis: |
A combinatorial library of 26,500 spiro[pyrrolidine-2,3'-oxindoles] was prepared in a single-compound format by a facile intermolecular 1,3-dipolar cycloaddition. An azomethine ylide, generated by the decarboxylative condensation of an isatin 1 with an alpha-amino acid 2, was trapped by a trans-chalcone 3 to afford heterocycles of the general structure 4. The regio-and stereochemistry of a representative product was determined by single crystal X-ray structure. (C) 1998 Elsevier Science Ltd. All rights reserved. Tetrahedron Lett |
