Influence of a proton pump inhibitor-based therapy on Helicobacter pylori strain selection
| Autor: | Hazell, S. L., Mitchell, H. M., Hanna, G., Daskalopoulos, G. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Helicobacter pylori/classification/*genetics/isolation & purification
Double-Blind Method Omeprazole/*analogs & derivatives/pharmacology/therapeutic use Biopsy Anti-Ulcer Agents/pharmacology/*therapeutic use Proton Pumps/*antagonists & inhibitors Humans Gastric Mucosa/microbiology Helicobacter Infections/*drug therapy/microbiology 2-Pyridinylmethylsulfinylbenzimidazoles Pyloric Antrum/microbiology Random Amplified Polymorphic DNA Technique |
| Popis: | The influence of the proton pump inhibitor lansoprazole on strain diversity in Helicobacter pylori infected patients was investigated. Multiple isolates of Helicobacter pylori obtained pre- and post-therapy from gastric antral and body biopsies in 22 patients were compared using the random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) for analysis. Post-therapy strains exhibiting novel RAPD-profiles were found in 5 of 22 patients (4 of 11 patients treated with lansoprazole alone and 1 of 11 patients treated with lansoprazole plus amoxicillin). Proton pump inhibition may affect the microecology of the stomach by influencing the colonisation patterns of specific strains. Eur J Clin Microbiol Infect Dis |
| Databáze: | OpenAIRE |
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