| Autor: |
Daines, R. A., Pendrak, I., Sham, K., Van Aller, G. S., Konstantinidis, A. K., Lonsdale, J. T., Janson, C. A., Qiu, X., Brandt, M., Khandekar, S. S., Silverman, C., Head, M. S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Popis: |
The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology model. This homology model was used to design analogues that would have both high affinity for the enzyme and appropriate aqueous solubility to facilitate cocrystallization studies. J Med Chem |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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