Zdroj: |
Ronco, C, Cruz, D, van Straaten, H O, Honore, P, House, A, Bin, D & Gibney, N 2008, ' Dialysis dose in acute kidney injury : no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study. ', Critical care (London, England), vol. 12, no. 5 . |
Popis: |
The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice. |