| Autor: |
Walboomers, J. M.M., Meijer, C. J.L.M., Steenbergen, R. D.M., Van Duin, M., Helmerhorst, Th J.M., Snijders, P. J.F. |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2000 |
| Zdroj: |
Walboomers, J M M, Meijer, C J L M, Steenbergen, R D M, Van Duin, M, Helmerhorst, T J M & Snijders, P J F 2000, ' Humaan papillomavirus en het ontstaan van baarmoederhalskanker : Concept van carcinogenese ', Nederlands Tijdschrift voor Geneeskunde, vol. 144, no. 35, pp. 1671-1674 . |
| Popis: |
Infection with high risk human papillomavirus (hrHPV) plays a central aetiological role in cervical cancer. Still, cervical carcinogenesis is a multistep process which requires other events in addition to hrHPV infection. Recent data have resulted in the following concept of cervical carcinogenesis: hrHPV infects normal squamous epithelium. In most cases this will not lead to a lesion or at worst give rise to a regressing low grade cervical intraepithelial neoplasia (CIN). Both phenomena involve viral clearance. Only persistent hrHPV infections will lead to a high grade CIN lesion, a subset of which may undergo malignant transformation. At the transition of CIN 2 to CIN 3 deregulated expression of the viral oncogenes E6 and E7 takes place, resulting in genetic instability. Subsequently, activation of the telomere-lengthening enzyme, telomerase occurs, as the result of which cells obtain an infinite replication capacity. Ultimately, successive allele losses occur at different chromosomal locations which, followed by a clonal outgrowth result in an invasive carcinoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
