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Purpose: The primary aim of our study was to compare the changes in physical activity, sleep, fatigue, pain, and quality of life levels before and during confinement in patients with Behçet’s Disease (BD) and Familial Mediterranean Fever (FMF) disease (FMFD). The secondary aim of the present study was to determine the exercise behavior of patients with BD and FMF during the Covid 19 Pandemic. Methods: A total of 21 patients with BD (mean age was 42 years, 57.1% were female) and 21 patients with FMF (Mean age was 39 years, 71.4% were female) were included in this cross sectional study. Internal Physical Activity Questionnaire- Short Form, Short Form 36 and Exercise Stages of Change Questionnaire were administered to all participants. Sleep satisfaction, fatigue and pain was assessed with the Numeric Rating Scale. Results: There were no significant differences in sociodemographic data and all outcome scores except sleep duration between the groups at baseline (p>0.05). Physical activity, pain, fatigue, sleep, and quality of life were compared with pre-confinement in both BD and FMF patients. It was found that the level of pain and fatigue increased in BD patients, and physical activity and quality of life decreased in both BD and FMF patients (p0,05). Fiziksel aktivite, ağrı, yorgunluk, uyku ve yaşam kalitesi hem Behçet hem de AAA hastalarında karantina öncesi ile karşılaştırıldı. Behçet hastalarında ağrı ve yorgunluk düzeyinin arttığı hem Behçet hem de AAA hastalarında ise fiziksel aktivite ve yaşam kalitesinin azaldığı bulundu (p |