| Autor: |
Pepele, Mustafa Sefa, Yücel, Neslihan, Öztanır, Mustafa Namık, Karadağ, Neşe, Takmaz, Ali Alper, Özyalın, Farma |
| Přispěvatelé: |
Pepele, Mustafa Sefa, Özyalın, Fatma |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Popis: |
It was aimed to investigate the utility of different fluid replacement therapies in the acute phase of a combined experimental traumatic brain injury and hemorrhagic shock model in terms of biochemical, hemostatic and pathological changes in the brain. 48 rats were divided up into 6 groups (n=8). Control group (S) rats were subjected to sham experimental hemorrhagic shock after which they underwent a sham operation, while trauma group (T) rats were subjected to hemorrhagic shock and subsequent head trauma with no treatment. Among the rats subjected to hemorrhagic shock and subsequent head trauma, those given 3% NaCl after this were named as HS group; those given HyperHeas [7.2% NaCl / 6% poly (O-2-Hydroxyethyl) starch] were named as HyperHS group; those given 0.9% NaCl were determined as NS group and those given ringer lactate as RL group. 24-hours later, the fluids’ effects were evaluated. The brain fluid content and INR levels were significantly higher in all the experimental groups when set against those in the NS group (p ranged 0.05). In conclusion, study findings support the safely use of normal saline and Ringer lactate solutions in prompt fluid resuscitation where both traumatic brain injury and hemorrhagic shock have occurred, based on the overall advantages pertaining to each critical prognostic parameter. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
