| Autor: |
Radulović, Jelena, Mančev, Zorica, Stanojević, Stanislava, Vasiljević, T., Kovačević-Jovanović, Vesna, Pešić, Gordana |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Journal of Neuroimmunology |
| Popis: |
The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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