| Autor: |
Koc, G., Ozdemir, A.A., Girgin, G., Akbal, C., Kirac, D., Avcilar, T., Guney, A.I. |
| Přispěvatelé: |
Koc, G., Ozdemir, A.A., Girgin, G., Akbal, C., Kirac, D., Avcilar, T., Guney, A.I., Yeditepe Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Popis: |
Objectives: To detect autosomal genetic defects and to determine candidate genes in Sertoli cell-only syndrome infertile men. Methods: Single-nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell-only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results: A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage-gated channel subfamily Q member 1. Conclusions: The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell-only syndrome. © 2018 The Japanese Urological Association BSAGC-YLP-040112-0002 This study was supported by a grant from the Research Foundation of Marmara University, Turkey (Project No: BSAGC-YLP-040112-0002). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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