| Autor: |
Turkay, R., Aydin, A.F., Bingul, I., Kucukgergin, C., Dogan-Ekici, I., Hocaoglu, E., Uysal, M. |
| Přispěvatelé: |
Turkay, R., Aydin, A.F., Bingul, I., Kucukgergin, C., Dogan-Ekici, I., Hocaoglu, E., Uysal, M., Yeditepe Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Our goalwas to evaluate the role of ultrasound (US) imaging in an experimental 2-hit steatofibrosis rat model. Nineteen female Sprague- Dawley rats were divided into 2 groups: control group (n = 6) and highfat diet carbontetrachloride (HFD-CCl4) group (n = 13) that was fed with HFD for 14 weeks. Ultrasound was performed to evaluate liver steatosis. The HFD-CCl4 group rats were divided further into 2 subgroups: HFD rats with liver steatosis [US (+) group; n = 6] and without steatosis [US (-) group; n = 7]. All rats in the subgroups were administered with CCl4. In bothUS(+) andUS(-) subgroups, steatosis score, fibrosis score, triglyceride, and hydroxyproline contents were markedly higher compared with the control group. When compared with the US (-) group, triglyceride and hydroxyproline contents were significantly higher in the US (+) group, whereas steatosis and fibrosis scores were not different. Ultrasound imaging may be useful to assess the success of a 2-hit experimental steatofibrosis model. © Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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