| Autor: |
Parlak, A.E., Cakmak, H., Sandal, S., Yılmaz, B., Sekerci, M., Karagöz Genc, Z., Karatepe, M. |
| Přispěvatelé: |
Parlak, A.E., Cakmak, H., Sandal, S., Yılmaz, B., Sekerci, M., Karagöz Genc, Z., Karatepe, M., Yeditepe Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Popis: |
In this study, the effects of the two Schiff base derivatives and their metal complexes were tested for MDA concentration, which is an indicator of lipid peroxidation, antioxidant vitamin A, vitamin E, and vitamin C levels in cell culture. A comparison was performed among the groups and it was observed that MDA, vitamin A, vitamin E, and vitamin C concentrations were statistically changed. According to the results, all compounds caused a significant oxidative stress without Zn complexes. Moreover, Mn(II), Cu(II), Zn(II), and Ni(II) complexes of Schiff bases derived from a condensation of 1,2-bis (p-aminophenoxy) ethane with naphthaldehydes and 4-methoxy benzaldehyde were examined in terms of antitumor activity against MCF-7 human breast cancer and L1210 murine leukemia cells. Furthermore, the derivatives were tested for antioxidative and prooxidative effects on MCF-7 breast cancer cells. The compounds which were tested revealed that there was an antitumor activity for MCF-7 and L 1210 cancer cells. Also, some of the compounds induced oxidative harmful. © 2018 Wiley Periodicals, Inc. 522 Firat University Scientific Research Projects Management Unit 104T363 The financial support of The TUBITAK Project Number 104T363 and Management Unit of Scientific Research Projects of Firat University (FUBAP) is gratefully acknowledged (Project Number 522). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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